There are 9 owner-reported engine complaints for the 2006 Ford E-450in NHTSA's database. These are unverified consumer reports and may not reflect confirmed defects.
PULLED UP TO STOP SIGN. WHEN MAKING RIGHT TURN, ONTO INTERSTATE FRONTAGE ROAD, THROTTLE QUIT WORKING, WRENCH LIGH AND CHECK ENGINE LIGHT CAME ON. COASTED TO SIDE OF ROAD. VEHICLE HAD TO BE TOWED IN TO FORD DEALER. WAS TOLD ELECTRONIC THROTTLE CONTROL SHUT DOWN VEHICLE, AND THROTTLE BODY WOULD HAVE TO BE REPLACED. HAD IT HAPPENED ANOTHER MINUTE LATTER IT WOULD HAVE FAILED IN THE MIDDLE OF AN INTERSTATE HIGHWAY.
VEHICLE WAS STARTED IN GARAGE, BACKED VEHICLE UP AND THERE WAS A LOUD EXPLOSION TYPE NOISE. MECHANIC SAID # 8 PLUG BLEW OUT CAUSING MAJOR MOTOR DAMAGE. *TR
THE ENGINE QUITE SEVERAL TIMES, THE LAST TIME THE VEHICLE WAS TOTALLY DEAD AND WOULDN'T RESTART. ALSO, THE EMERGENCY FLASHERS WERE INOPERATIVE. *TR
TWICE THE ENGINE IN THIS VEHICLE HAS QUIT WITHOUT WARNING AT HIGHWAY SPEEDS. 1ST ON 9/1/2008 @ 27,300 MILES, 2ND ON 6/23/2009 @ 35,400 MILES. IN BOTH CASES THE VEHICLE WAS RESTARTED AS SOON AS SAFELY POSSIBLE. THIS ISSUE COULD RESULT IN A SERIOUS INJURY AND/OR PROPERTY DAMAGE SINCE THERE IS A LOSS OF STEERING AND BRAKE CONTROLS WHEN THE ENGINE QUITS. THE DEALER HAS TRIED TO REPAIR BUT CANNOT DIAGNOSE THE PROBLEM. I HAVE EMAILED FORD MOTOR ASKING THAT THEY HAVE A TECHNICIAN CONTACT THE DEALER TO WORK TOGETHER TO CORRECT THIS DEFECT ASAP. IN THE MEANTIME I AM CONCERNED THAT DRIVING THE VEHICLE IS DANGEROUS TO MYSELF AND OTHERS. *TR
ENGINE LOSS OF POWER. MULTIPLE TIMES OVER THE YEARS REQUIRING REPAIRS THAT NEVER RESOLVED THE ISSUE. AMBULANCE SERVICE ENDED UP HAVING TO PULL FROM SERVICE BECAUSE OF FREQUENCY. *TR
TL*THE CONTACT OWNS A 2006 FORD E450. DURING RAINY WEATHER CONDITIONS, THE ENGINE WILL NOT TURN ON. THE ENGINE ALSO STALLS IF IT BEGINS TO RAIN WHILE DRIVING AND WILL NOT RESTART. THE SPEED WAS NOT A FACTOR. EACH TIME THE FAILURE OCCURRED, THE VEHICLE WAS TOWED TO THE FORD DEALER AND AFTER A FEW DAYS THEY WERE ABLE TO RESTART THE ENGINE. THE MECHANICS HAVE NOT BEEN ABLE TO DIAGNOSE THE FAILURE. THE VIN WAS UNAVAILABLE. THE FAILURE MILEAGE WAS 9,000 AND THE CURRENT MILEAGE WAS 15,333.
THE SCHOOL BUS WAS ON PARKED AT 10:00 AM AT 1:15 PM OUR SHOP NOTICED SMOKE COMING FROM THE PARKING YARD. THEY FOUND THE ENGINE COMPARTMENT AND FRONT OF BUS WAS ON FIRE. THE VAN WAS A TOTAL LOSS. *TR
The contact owns a 2006 Ford E-450. The contact stated while driving 15 MPH there was a high-pressure oil leak. There were no warning lights illuminated. The vehicle was taken to an independent mechanic who diagnosed the failure to be high-pressure oil leak and EGR failure. The vehicle was repaired; however, failure reoccurred. The manufacturer was notified of the failure. The approximate failure mileage was 64,000.
(2) 2006 E450 SERIES FORD AMBULANCES, ENGINE PROBLEMS. *NM
Complaints are unverified consumer reports submitted to NHTSA. A high complaint count may reflect vehicle popularity, not defect severity. Data sourced from NHTSA public records.
Data synced from NHTSA on May 4, 2026