There are 4 owner-reported engine complaints for the 2021 Ford E-450in NHTSA's database. These are unverified consumer reports and may not reflect confirmed defects.
Engine camshaft and lifters failed. Truck is at a Ford dealer. Engine could fail in the middle of the road, causing an accident. This is our eighth vehicle with the same issue taken to a ford dealer in the past year. A little knocking noise started that quickly turned into a loud knocking/rattling noise. No lights came on the truck.
This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.
Engine Camshaft and lifters failed, unit was inspected by ford dealer and engine had to be replaced. Engine can stop working and truck could break down in the middle of the road. No warning lamps, just a loud knocking sound when brakes were applied and truck was downshifting to stop. A lot of other people that purchased these ford light duty trucks with the 7.3L engine are having the same issue.
Engine camshaft and lifters failed and were inspected by Ford dealer, which corrected the issue by replacing the engine. Engine can failed and truck get stuck in the middle of the road. In the past 6 months its our 4th Ford truck with the same issue and a lot of other Fedex contractors that purchased a Ford truck with the 7.3L engine are reporting the same issue. No warning light was on in this vehicle, just started with a knocking sound that got worse until it got to the dealer and engine had to be replaced
Complaints are unverified consumer reports submitted to NHTSA. A high complaint count may reflect vehicle popularity, not defect severity. Data sourced from NHTSA public records.
Data synced from NHTSA on May 4, 2026