There are 3 stored owner reports matching the powertrain & transmission leading-label group for the 2021 Mercedes-Benz E-Class in our NHTSA-sourced dataset. These are unverified consumer reports and may not reflect confirmed defects.
This group counts stored reports whose component label starts with one of this site's matching prefixes, ignoring case. Each matching report counts once within the group. Components mentioned later in the label or only in the narrative are not searched. How component counts work
Loaded 3 of 3 matching reports.
Open the full vehicle complaint log (all categories)Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the E-Class. My VIN was not included in the recall campaign but my vehicle is experiencing these exact symptoms as referenced in the first sentence. My vehicle has 48,000 miles.
With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .
The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.
Complaints are unverified consumer reports submitted to NHTSA. A high complaint count may reflect vehicle popularity, not defect severity. Data sourced from NHTSA public records.
NHTSA source checks for this vehicle year
Checks are recorded separately for each dataset, not for the whole page. Dates use UTC. A missing check date does not mean no records exist.
Vehicle import recorded: Aug 31, 2026. This is the stored import date, not confirmation that every source was successfully refreshed.